Name: Hotel Museo Spa Casa Santo Domingo
Price range: $303 total
Rating: 9.2

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Central Highlands Vacation

Leave all the planning up to us with a Central Highlands vacation package. With everything organized before you depart, all you need to do is sit back, chill out and enjoy this destination's culture and charm. Your trip to Central Highlands wouldn't be complete without spending some time in its most renowned cities, starting with Guatemala City. A couple of the top attractions here include Paseo Cayala and La Aurora Zoo. Chiquimula is another favorite city with Central Highlands travelers. Visitors to this destination enjoy Ismael Cerna Park and Nuestra Senora del Transito Church. Expedia is your one-stop shop when it comes to planning your Central Highlands vacation. From hotels and flights, to activities and more, we know how to curate a travel experience like no other.

The Latest Central Highlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Le Suisse Spa

Save 100% on your flight

$648

per person

Aug 16 - Aug 22

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Guatemala City (GUA)

8.4/10 Very Good! (27 reviews)

I 100% recommend Le Suisse Spa. The facilities are first-class, the room was super clean, and the service was excellent. The staff made us feel very comfortable. We will definitely be coming back soon.

Reviewed on May 25, 2026

Casa Faustina Boutique Hotel

$1,065

per person

Aug 6 - Aug 11

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

8.8/10 Excellent! (117 reviews)

Hermoso lugar, no se diga la atención y la amabilidad, el desayuno exquisito, ame un detalle de su filtro de agua para tomar en la habitación Repetiría mi estancia con ellos 100/100

Reviewed on May 12, 2026

Hotel Soleil La Antigua

$684

per person

Aug 2 - Aug 5

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

8.6/10 Excellent! (1,002 reviews)

The good - the property has beautiful lawn and a nice pool. Staff was helpful. They have a free shuttle that takes you about a kilometer and drops you close to Central Park. Breakfast was good. The bad - the building is pretty run down. The toilet was very dirty and we had to request room change. In new room bathroom got clogged and had yellow water. They tried and somewhat fixed it, but I think they have old plumbing issue. They charge cars about $3 for parking. It can be validated for taxis dropping and picking you. But not all taxis know it and it creates confusion with taxis refusing to come to the premises.

Reviewed on May 11, 2026

Barbaras Boutique Hostel

$985

per person

Jul 29 - Aug 4

found 1 day ago

Roundtrip flight included

Los Angeles (LAX) to Guatemala City (GUA)

10/10 Exceptional! (32 reviews)

Wonderful social scene to meet new people. The morning breakfast brought everyone together.

Reviewed on Jan 18, 2026

Pensativo House Hotel

$1,196

per person

Jul 31 - Aug 6

found 8 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

9.4/10 Exceptional! (414 reviews)

A really special hotel in Antigua.

Reviewed on May 25, 2026

Don't see what you're looking for?

See all available trips from Columbus to Central Highlands

View all trips

Where to stay in Central Highlands

Find the best Central Highlands areas and neighborhoods for the activities you enjoy most. Learn more about Central Highlands

Quetzaltenango Central Park in the morning - Parque a Centro América Xela - Guatemala

Zona 10

1 out of top 10 points of interest in this area

4.5/5(509 area reviews)

Zona 10 is known for its ample dining options, and you can make a stop by Oakland Mall and Plaza Fontabella Shopping Center while in the area.

Discover the most popular places to visit in Central Highlands

Antigua Guatemala Cathedral

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

Central Park

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Cayala city touristic attraction in Guatemala, Central America

Paseo Cayala

During your trip to Guatemala City, you can browse for the perfect souvenirs at Paseo Cayala. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Central Highlands Hotel Deals

Barceló Guatemala City

7 Avenida 15-45, Zona 9 Guatemala City Guatemala

Fully refundableReserve now, pay when you stay

$103 nightly

$126 total

Jun 21 - Jun 22

Total with taxes and fees

9.2/10 Wonderful! (3,316 reviews)

"Good value"

Reviewed on May 27, 2026

Tikal Futura Hotel & Convention Center

Calzada Roosevelt 22-43 Guatemala City Guatemala

Fully refundableReserve now, pay when you stay

$114 nightly

$140 total

May 31 - Jun 1

Total with taxes and fees

9.2/10 Wonderful! (1,012 reviews)

"The pool was great, including the food served in that area."

Reviewed on May 27, 2026

Hotel Museo Spa Casa Santo Domingo

3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez

Fully refundableReserve now, pay when you stay

$249 nightly

$303 total

Jun 21 - Jun 22

Total with taxes and fees

9.2/10 Wonderful! (1,059 reviews)

"Hermosas areas verdes."

Reviewed on May 24, 2026

See all 1,316 properties in Central Highlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.