Name: Hotel Museo Spa Casa Santo Domingo
Price range: $256 total
Rating: 9.2

Your Central Highlands Vacation

Leave all the planning up to us with a Central Highlands vacation package. With everything organized before you depart, all you need to do is sit back, chill out and enjoy this destination's culture and charm. Your trip to Central Highlands wouldn't be complete without spending some time in its most renowned cities, starting with Guatemala City. A couple of the top attractions here include Paseo Cayala and La Aurora Zoo. Chiquimula is another favorite city with Central Highlands travelers. Visitors to this destination enjoy Ismael Cerna Park and Nuestra Senora del Transito Church. Expedia is your one-stop shop when it comes to planning your Central Highlands vacation. From hotels and flights, to activities and more, we know how to curate a travel experience like no other.

The Latest Central Highlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Hot Chipilin

Historic Center

Save 100% on your flight

$378

per person

Nov 13 - Nov 17

found 1 day ago

Roundtrip flight included

Houston (IAH) to Guatemala City (GUA)

8.2/10 Very Good! (38 reviews)

Very nice and accommodating staff. The room and facilities were great and beautiful.

Reviewed on Jul 2, 2025

Hotel Soleil Pacifico

Save 100% on your flight

$825

per person

Oct 16 - Oct 22

found 1 day ago

Roundtrip flight included

New York (JFK) to Guatemala City (GUA)

7/10 Good! (343 reviews)

areas es espectacular

Reviewed on Jun 30, 2025

Hotel Soleil La Antigua

Save 100% on your flight

$469

per person

Oct 31 - Nov 4

found 1 day ago

Roundtrip non-stop flight included

Houston (IAH) to Guatemala City (GUA)

8.6/10 Excellent! (1,002 reviews)

Minibar in the room was locked. Room keys did not work had to swap them twice. Complimetary coffee in the room was limited to the first night only on a multiple night stay. The bar had some liquor bottles prices 3 or 4 times over market value. The hotel is really nice, but for the price they are changing per room complimentary coffee and razors should be a norm. Charging for these items made it felt cheap as if we were nickeled and dimed for everything.

Reviewed on Aug 18, 2025

Casa Santa Margarita

Save 100% on your flight

$1,631

per person

Oct 31 - Nov 4

found 1 day ago

Roundtrip non-stop flight included

Houston (IAH) to Guatemala City (GUA)

10/10 Exceptional! (8 reviews)

Everything was great, specially the service, they were always really attentive and their breakfast is really good (homemade). Quiet and safe, it’s set on a closed community and has a guard on the gates. Uber is very accessible. 10/10 would visit again!

Reviewed on Aug 17, 2025

Hotel Camino Real Antigua

Historic Center

Save 100% on your flight

$704

per person

Nov 13 - Nov 17

found 1 day ago

Roundtrip flight included

Houston (IAH) to Guatemala City (GUA)

9.6/10 Exceptional! (1,002 reviews)

staff was soo friendly. Rooms cleans and service was amazing. close to everything and view of volcano is amazing

Reviewed on Aug 19, 2025

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Where to stay in Central Highlands

Find the best Central Highlands areas and neighborhoods for the activities you enjoy most. Learn more about Central Highlands

Zona 10

2 out of top 10 points of interest in this area

4.5/5(505 area reviews)

Zona 10 is known for its ample dining options, and you can make a stop by Oakland Mall and Plaza Fontabella Shopping Center while in the area.

Discover the most popular places to visit in Central Highlands

Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this romantic area.

Central Park

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Antigua Guatemala Cathedral

You can find out about the history of Antigua Guatemala with a visit to Antigua Guatemala Cathedral. Discover the area's shops, or seek out its local tours.

Central Highlands Hotel Deals

Barceló Guatemala City

7 Avenida 15-45, Zona 9, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$81 nightly

$99 total

Aug 31 - Sep 1

Total with taxes and fees

9/10 Wonderful! (2,971 reviews)

"Friendly staff and the hotel was always very clean. Amazing service. I always enjoy my stay at Barceló."

Reviewed on Aug 21, 2025

Tikal Futura Hotel & Convention Center

Calzada Roosevelt 22-43, Zona 11, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$106 nightly

$129 total

Sep 7 - Sep 8

Total with taxes and fees

8.8/10 Excellent! (1,003 reviews)

Amazing Value for your stay

"3rd time staying here. Staff is always so friendly. So nice to have the indoor pool very family friendly. The mall is walking distance with plenty of dining and shopping options."

Reviewed on Aug 18, 2025

Hotel Museo Spa Casa Santo Domingo

3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez

Fully refundableReserve now, pay when you stay

$210 nightly

$256 total

Aug 24 - Aug 25

Total with taxes and fees

9.2/10 Wonderful! (1,001 reviews)

"Beautiful hotel as always"

Reviewed on Aug 16, 2025

See all 1,207 properties in Central Highlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.